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ENZYME

ENZYME entry: EC 1.5.1.28

Accepted Name
opine dehydrogenase
Reaction catalysed
(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate
Comment(s)
  • in the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine.
  • Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate.
  • In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor.
  • They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine.
  • The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate.
Cross-references
BRENDA1.5.1.28
EC2PDB1.5.1.28
ExplorEnz1.5.1.28
PRIAM enzyme-specific profiles1.5.1.28
KEGG Ligand Database for Enzyme Nomenclature1.5.1.28
IUBMB Enzyme Nomenclature1.5.1.28
IntEnz1.5.1.28
MEDLINEFind literature relating to 1.5.1.28
MetaCyc1.5.1.28
Rhea expert-curated reactions1.5.1.28
UniProtKB/Swiss-Prot
Q44297, ODH_ARTSC

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