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ENZYME

ENZYME entry: EC 2.1.1.100

Accepted Name
protein-S-isoprenylcysteine O-methyltransferase
Alternative Name(s)
isoprenylcysteine carboxylmethyltransferase
prenylated protein carboxyl methyltransferase
prenylcysteine carboxyl methyltransferase
Reaction catalysed
[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine
Comment(s)
  • C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, more slowly.
  • Formerly EC 2.1.1.24.
Cross-references
BRENDA2.1.1.100
EC2PDB2.1.1.100
ExplorEnz2.1.1.100
PRIAM enzyme-specific profiles2.1.1.100
KEGG Ligand Database for Enzyme Nomenclature2.1.1.100
IUBMB Enzyme Nomenclature2.1.1.100
IntEnz2.1.1.100
MEDLINEFind literature relating to 2.1.1.100
MetaCyc2.1.1.100
Rhea expert-curated reactions2.1.1.100
UniProtKB/Swiss-Prot
Q9FMW9, ICMTA_ARATHQ93W54, ICMTB_ARATHQ558K8, ICMT_DICDI
O60725, ICMT_HUMANQ8TMG0, ICMT_METACQ9EQK7, ICMT_MOUSE
A2XX73, ICMT_ORYSIQ7XSR9, ICMT_ORYSJQ9WVM4, ICMT_RAT
D6WJ77, ICMT_TRICAO12947, ICMT_XENLAP87014, MAM4_SCHPO
P32584, STE14_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-