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ENZYME

ENZYME entry: EC 3.4.21.75

Accepted Name
furin
Alternative Name(s)
dibasic processing enzyme
paired basic amino acid residue cleaving enzyme
prohormone convertase
Reaction catalysed
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors
Comment(s)
  • Activated by calcium.
  • Belongs to peptidase family S8.
Cross-references
BRENDA3.4.21.75
EC2PDB3.4.21.75
ExplorEnz3.4.21.75
PRIAM enzyme-specific profiles3.4.21.75
KEGG Ligand Database for Enzyme Nomenclature3.4.21.75
IUBMB Enzyme Nomenclature3.4.21.75
IntEnz3.4.21.75
MEDLINEFind literature relating to 3.4.21.75
MetaCyc3.4.21.75
Rhea expert-curated reactions3.4.21.75
UniProtKB/Swiss-Prot
A0A044RE18, BLI_ONCVOP26016, FUR11_DROMEP30430, FUR1C_DROME
P30432, FUR2_DROMEP29119, FURI1_XENLAQ28193, FURIN_BOVIN
P09958, FURIN_HUMANP23188, FURIN_MOUSEP23377, FURIN_RAT

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