PROSITE documentation PDOC00408

{PDOC00408}
{PS00933; FGGY_KINASES_1}
{PS00445; FGGY_KINASES_2}
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* FGGY family of carbohydrate kinases signatures *
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It has been shown [1] that four different type of carbohydrate kinases seem to
be evolutionary related. These enzymes are:

 - L-fuculokinase (EC 2.7.1.51) (gene fucK).
 - Gluconokinase (EC 2.7.1.12) (gene gntK).
 - Glycerokinase (EC 2.7.1.30) (gene glpK).
 - Xylulokinase (EC 2.7.1.17) (gene xylB).
 - L-xylulose kinase (EC 2.7.1.53) (gene lyxK).

These enzymes are proteins of from 480 to 520 amino acid residues.

As consensus  patterns for this  family  of  kinases we selected two conserved
regions, one in the central section, the other in the C-terminal section.

-Consensus pattern: [MFYGS]-x-[PST]-x(2)-K-[LIVMFYW]-{G}-W-[LIVMF]-{E}-
                    [DENQTKR]-[ENQH]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for lyxK.
-Other sequence(s) detected in Swiss-Prot: 5.

-Consensus pattern: [GSA]-x-[LIVMFYW]-{D}-G-[LIVM]-x(7,8)-[HDENQ]-[LIVMF]-
                    {PEQ}-{DTAI}-[AS]-[STALIVM]-[LIVMFY]-[DEQ]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: 20.

-Last update: April 2006 / Pattern revised.

[ 1] Reizer A., Deutscher J., Saier M.H. Jr., Reizer J.
     "Analysis of the gluconate (gnt) operon of Bacillus subtilis."
     Mol. Microbiol. 5:1081-1089(1991).
     PubMed=1659648

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