PROSITE documentation PDOC01019

{PDOC01019}
{PS01315; CDS}
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* Phosphatidate cytidylyltransferase signature *
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Phosphatidate cytidylyltransferase  (EC  2.7.7.41) [1,2,3] (also known as CDP-
diacylglycerol synthase)  (CDS)  is the enzyme that catalyzes the synthesis of
CDP-diacylglycerol from CTP  and phosphatidate (PA).  CDP-diacylglycerol is an
important branch   point  intermediate  in  both  prokaryotic  and  eukaryotic
organisms. CDS  is a membrane-bound enzyme. As a signature pattern we selected
a conserved region located in the C-terminal part.

-Consensus pattern: S-x-[LIVMF]-K-R-x(4)-K-D-x-[GSA]-x(2)-[LIF]-[PGS]-x-H-G-G-
                    [LIVMF]-x-D-R-[LIVMFT]-D
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Sparrow C.P., Raetz C.R.H.
     "Purification and properties of the membrane-bound CDP-diglyceride
     synthetase from Escherichia coli."
     J. Biol. Chem. 260:12084-12091(1985).
     PubMed=2995359
[ 2] Shen H., Heacock P.N., Clancey C.J., Dowhan W.
     "The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces
     cerevisiae is essential for cell growth."
     J. Biol. Chem. 271:789-795(1996).
     PubMed=8557688
[ 3] Saito S., Goto K., Tonosaki A., Kondo H.
     "Gene cloning and characterization of CDP-diacylglycerol synthase from
     rat brain."
     J. Biol. Chem. 272:9503-9509(1997).
     PubMed=9083091

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