PROSITE documentation PDOC00709

{PDOC00709}
{PS00914; SYNTAXIN}
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* Syntaxin / epimorphin family signature *
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The following proteins have been shown to be evolutionary related [1,2,3]:

 - Epimorphin (or syntaxin 2),  a mammalian mesenchymal protein which plays an
   essential role in epithelial morphogenesis.
 - Syntaxin  1A  (also  known  as  antigen  HPC-1)  and  syntaxin 1B which are
   synaptic proteins  which may be involved in docking of synaptic vesicles at
   presynaptic active zones.
 - Syntaxin 3.
 - Syntaxin  4,  which is potentially involved in docking of synaptic vesicles
   at presynaptic active zones.
 - Syntaxin 5, which mediates endoplasmic reticulum to golgi transport.
 - Syntaxin 6, which is involved in intracellular vesicle trafficking.
 - Syntaxin 7.
 - Yeast  PEP12  (or VPS6) which is required for the transport of proteases to
   the vacuole.
 - Yeast  SED5 which is required for the fusion of transport vesicles with the
   Golgi complex.
 - Yeast SSO1 and SSO2  which are  required for vesicle fusion with the plasma
   membrane.
 - Yeast VAM3, which is required for vacuolar assembly.
 - Arabidopsis thaliana protein KNOLLE which may be involved in cytokinesis.
 - Caenorhabditis elegans hypothetical proteins F35C8.4, F48F7.2, F55A11.2 and
   T01B11.3.

The above  proteins  share  the following characteristics: a size ranging from
30 Kd  to  40  Kd;  a  C-terminal extremity which is highly hydrophobic and is
probably involved  in  anchoring  the protein to the membrane; a central, well
conserved region, which seems to be in a coiled-coil conformation.

The pattern specific for  this family is based on the most conserved region of
the coiled coil domain.

-Consensus pattern: [RQLKA]-x(3)-[LIVMAW]-x(2)-[LIVM]-[ESHLKAGQV]-x(2)-
                    [LIVMT]-x-[DEVMNRAST]-[LIVMT]-x(2)-[LIVMQ]-[FSAQGVM]-x(2)-
                    [LIVMF]-x(3)-[LIVT]-x(2)-Q-[GADEQVST]-x(2)-[LIVMA]-
                    [DNQTEI]-x-[LIVMF]-[DESVHAG]-x(2,3)-[LIVM]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Bennett M.K., Garcia-Arraras J.E., Elferink L.A., Peterson K.,
     Fleming A.M., Hazuka C.D., Scheller R.H.
     "The syntaxin family of vesicular transport receptors."
     Cell 74:863-873(1993).
     PubMed=7690687
[ 2] Spring J., Kato M., Bernfield M.
     "Epimorphin is related to a new class of neuronal and yeast vesicle
     targeting proteins."
     Trends Biochem. Sci. 18:124-125(1993).
     PubMed=8493722
[ 3] Pelham H.R.B.
     "Is epimorphin involved in vesicular transport?"
     Cell 73:425-426(1993).
     PubMed=8490959

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