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{PDOC00756}
{PS00983; LY6_UPAR}
{BEGIN}
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* Ly-6 / u-PAR domain signature *
*********************************

A variety of GPI-linked cell-surface glycoproteins are composed of one or more
copies of a conserved domain  of  about  100 amino-acid residues [1,2].  These
proteins are:

 - Urokinase  plasminogen  activator  surface  receptor  u-PAR, which binds to
   u-PA and is responsible for its proteolysis-independent signal transduction
   activation effects.
 - The mouse family of Ly-6 T-cell antigens (Ly-6A, -6C, -6E, -6F and -6G).
 - CD59  (MACIF  or  MIRL),  an  inhibitor  of  the complement membrane attack
   complex action.
 - Herpesvirus saimiri CD59-related protein (gene 15).
 - Mouse thymocyte B cell antigen (ThB).
 - Squid glycoprotein Sgp-2.

U-PAR contains  three  tandem  copies  of the domain, while all the others are
made up of a single domain.

As shown  in  the  following  schematic,  this  conserved  domain  contains 10
cysteine residues  involved in five disulfide bonds - in u-PAR, the first copy
of the domain lacks the fourth disulfide bond.

     +------+     +------------------------+                    +---+
     |      |     |                        |                    |   |
 xCxxCxxxxxxCxxxxxCxxxxxCxxxxxxxxxxxxxxxxxxCxxxxCxxxxxxxxxxxxxxCCxxxCxxxxxxxx
  |                     |                       |              |
  +---------------------+                       +--------------+

'C': conserved cysteine involved in a disulfide bond.

The signature  pattern  that  detects this domain starts towards its extremity
and ends at the sixth cysteine.

-Consensus pattern: [EQR]-C-[LIVMFYAH]-x-C-x(5,8)-C-x(3,8)-[EDNQSTV]-C-{C}-
                    x(5)-C-x(12,24)-C
                    [The 6 C's are involved in disulfide bonds]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Behrendt N., Ploug M., Patthy L., Houen G., Blasi F., Dano K.
     "The ligand-binding domain of the cell surface receptor for
     urokinase-type plasminogen activator."
     J. Biol. Chem. 266:7842-7847(1991).
     PubMed=1850423
[ 2] Ploug M., Kjalke M., Ronne E., Weidle U., Hoyer-Hansen G., Dano K.
     "Localization of the disulfide bonds in the NH2-terminal domain of the
     cellular receptor for human urokinase-type plasminogen activator. A
     domain structure belonging to a novel superfamily of
     glycolipid-anchored membrane proteins."
     J. Biol. Chem. 268:17539-17546(1993).
     PubMed=8394346

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