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{PDOC00906}
{PS01177; ANAPHYLATOXIN_1}
{PS01178; ANAPHYLATOXIN_2}
{BEGIN}
**********************************************
* Anaphylatoxin domain signature and profile *
**********************************************

Anaphylatoxins [1]  are  mediators  of  local inflammatory process that act by
inducing smooth muscle contraction. There are three  different anaphylatoxins:
C3a, C4a  and  C5a. They are peptides of about 75 amino-acid residues that are
derived from the proteolytic degradation of complement C3, C4 and C5 and which
contains six  disulfide-bonded cysteines [2] (see the schematic representation
below).

                          +--------------------+
            +-------------|------------+       |
            |             |            |       |
         xxxCCxxxxxxxxxxxxCxxxxxxxxxxxxCxxxxxxCCxxx
             |                                |
             +--------------------------------+

'C': conserved cysteine involved in a disulfide bond.

This cysteine-rich region shares similarity with a three times repeated domain
found in  the  mammalian extracellular matrix proteins fibulins 1 and 2 [3,4].
The three disulfide bonds are conserved in the first and last repeats, but the
first disulfide bond is missing in the second repeat.

Our consensus pattern spans the entire cysteine-rich domain.

-Consensus pattern: [CSH]-C-x(2)-[GAP]-x(7,8)-[GASTDEQR]-C-[GASTDEQL]-x(3,9)-
                    [GASTDEQN]-x(2)-[CE]-x(6,7)-C-C
                    [The 6 C's are involved in disulfide bonds]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: May 2004 / Text revised.

[ 1] Hugli T.E.
     "Biochemistry and biology of anaphylatoxins."
     Complement 3:111-127(1986).
     PubMed=3542363
[ 2] Huber R., Scholze H., Paques E.P., Deisenhofer J.
     "Crystal structure analysis and molecular model of human C3a
     anaphylatoxin."
     Hoppe-Seyler's Z. Physiol. Chem. 361:1389-1399(1980).
     PubMed=7439885
[ 3] Argraves W.S., Tran H., Burgess W.H., Dickerson K.
     "Fibulin is an extracellular matrix and plasma glycoprotein with
     repeated domain structure."
     J. Cell Biol. 111:3155-3164(1990).
     PubMed=2269669
[ 4] Pan T.-C., Sasaki T., Zhang R.-Z., Faessler R., Timpl R., Chu M.L.
     "Structure and expression of fibulin-2, a novel extracellular matrix
     protein with multiple EGF-like repeats and consensus motifs for
     calcium binding."
     J. Cell Biol. 123:1269-1277(1993).
     PubMed=8245130

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