PROSITE entry PS00139
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ID THIOL_PROTEASE_CYS; PATTERN.
AC PS00139;
DT 01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
DE Eukaryotic thiol (cysteine) proteases cysteine active site.
PA Q-{V}-x-{DE}-[GE]-{F}-C-[YW]-{DN}-x-[STAGC]-[STAGCV].
NR /RELEASE=2024_02,571282;
NR /TOTAL=297(297); /POSITIVE=280(280); /UNKNOWN=0(0); /FALSE_POS=17(17);
NR /FALSE_NEG=57; /PARTIAL=21;
CC /TAXO-RANGE=??EPV; /MAX-REPEAT=1;
CC /SITE=7,active_site;
CC /VERSION=2;
DR Q91FG3 , 361L_IIV6 , T; P00785 , ACTN_ACTCC , T;
DR A5HII1 , ACTN_ACTDE , T; Q8RWQ9 , ALEUL_ARATH, T;
DR Q8H166 , ALEU_ARATH , T; P05167 , ALEU_HORVU , T;
DR P80884 , ANAN_ANACO , T; A0A509APV9, BHPC1_PLABA, T;
DR B3LP78 , BLH1_YEAS1 , T; C7GPC1 , BLH1_YEAS2 , T;
DR B5VQH0 , BLH1_YEAS6 , T; A6ZRK4 , BLH1_YEAS7 , T;
DR C8ZFZ7 , BLH1_YEAS8 , T; Q01532 , BLH1_YEAST , T;
DR P87362 , BLMH_CHICK , T; Q13867 , BLMH_HUMAN , T;
DR Q8R016 , BLMH_MOUSE , T; P13019 , BLMH_RABIT , T;
DR P70645 , BLMH_RAT , T; O23791 , BROM1_ANACO, T;
DR P14518 , BROM2_ANACO, T; Q9HC96 , CAN10_HUMAN, T;
DR Q95LP4 , CAN10_MACFA, T; Q9ESK3 , CAN10_MOUSE, T;
DR Q9ES66 , CAN10_RAT , T; Q9UMQ6 , CAN11_HUMAN, T;
DR Q6J756 , CAN11_MOUSE, T; Q4V8Q1 , CAN11_RAT , T;
DR Q6ZSI9 , CAN12_HUMAN, T; Q9ER56 , CAN12_MOUSE, T;
DR Q3UW68 , CAN13_MOUSE, T; Q5BK10 , CAN13_RAT , T;
DR A8MX76 , CAN14_HUMAN, T; O75808 , CAN15_HUMAN, T;
DR Q9JLG8 , CAN15_MOUSE, T; Q27970 , CAN1_BOVIN , T;
DR P07384 , CAN1_HUMAN , T; Q9GLG2 , CAN1_MACFA , T;
DR O35350 , CAN1_MOUSE , T; P35750 , CAN1_PIG , T;
DR Q5NVS7 , CAN1_PONAB , T; P97571 , CAN1_RAT , T;
DR Q27971 , CAN2_BOVIN , T; Q92178 , CAN2_CHICK , T;
DR P17655 , CAN2_HUMAN , T; Q9GLG1 , CAN2_MACFA , T;
DR O08529 , CAN2_MOUSE , T; Q07009 , CAN2_RAT , T;
DR P51186 , CAN3_BOVIN , T; Q92177 , CAN3_CHICK , T;
DR P20807 , CAN3_HUMAN , T; Q9GLG7 , CAN3_MACFA , T;
DR Q64691 , CAN3_MOUSE , T; P43368 , CAN3_PIG , T;
DR P16259 , CAN3_RAT , T; Q9TTH8 , CAN3_SHEEP , T;
DR Q22036 , CAN5_CAEEL , T; O15484 , CAN5_HUMAN , T;
DR O08688 , CAN5_MOUSE , T; Q8R4C0 , CAN5_RAT , T;
DR A6NHC0 , CAN8_HUMAN , T; Q91VA3 , CAN8_MOUSE , T;
DR Q78EJ9 , CAN8_RAT , T; O14815 , CAN9_HUMAN , T;
DR Q9D805 , CAN9_MOUSE , T; O35920 , CAN9_RAT , T;
DR Q11002 , CANA_DROME , T; Q9VT65 , CANB_DROME , T;
DR P27398 , CAND_DROME , T; P00789 , CANX_CHICK , T;
DR P34308 , CAN_CAEEL , T; P27730 , CAN_SCHMA , T;
DR Q91ZF2 , CAT7_MOUSE , T; D3ZZ07 , CAT7_RAT , T;
DR P92131 , CATB1_GIAIN, T; Q93VC9 , CATB2_ARATH, T;
DR P92132 , CATB2_GIAIN, T; Q94K85 , CATB3_ARATH, T;
DR P92133 , CATB3_GIAIN, T; P07688 , CATB_BOVIN , T;
DR P43233 , CATB_CHICK , T; P07858 , CATB_HUMAN , T;
DR Q4R5M2 , CATB_MACFA , T; A0A072UTP9, CATB_MEDTR , T;
DR P10605 , CATB_MOUSE , T; A1E295 , CATB_PIG , T;
DR Q5R6D1 , CATB_PONAB , T; P00787 , CATB_RAT , T;
DR P83205 , CATB_SHEEP , T; Q3ZCJ8 , CATC_BOVIN , T;
DR O97578 , CATC_CANLF , T; P53634 , CATC_HUMAN , T;
DR Q60HG6 , CATC_MACFA , T; P97821 , CATC_MOUSE , T;
DR Q5RB02 , CATC_PONAB , T; P80067 , CATC_RAT , T;
DR Q9UBX1 , CATF_HUMAN , T; Q9R013 , CATF_MOUSE , T;
DR Q3T0I2 , CATH_BOVIN , T; P09668 , CATH_HUMAN , T;
DR P49935 , CATH_MOUSE , T; O46427 , CATH_PIG , T;
DR P00786 , CATH_RAT , T; Q9R014 , CATJ_MOUSE , T;
DR Q63088 , CATJ_RAT , T; Q5E968 , CATK_BOVIN , T;
DR Q3ZKN1 , CATK_CANLF , T; Q90686 , CATK_CHICK , T;
DR P43235 , CATK_HUMAN , T; P61276 , CATK_MACFA , T;
DR P61277 , CATK_MACMU , T; P55097 , CATK_MOUSE , T;
DR Q9GLE3 , CATK_PIG , T; P43236 , CATK_RABIT , T;
DR O35186 , CATK_RAT , T; P25975 , CATL1_BOVIN, T;
DR Q9GL24 , CATL1_CANLF, T; P09648 , CATL1_CHICK, T;
DR Q9GKL8 , CATL1_CHLAE, T; P07711 , CATL1_HUMAN, T;
DR P06797 , CATL1_MOUSE, T; Q94714 , CATL1_PARTE, T;
DR Q28944 , CATL1_PIG , T; P07154 , CATL1_RAT , T;
DR Q10991 , CATL1_SHEEP, T; Q5E998 , CATL2_BOVIN, T;
DR O60911 , CATL2_HUMAN, T; A0E358 , CATL2_PARTE, T;
DR Q24940 , CATLL_FASHE, T; O97397 , CATLL_PHACE, T;
DR O17473 , CATL_BRUPA , T; Q95029 , CATL_DROME , T;
DR Q26636 , CATL_SARPE , T; Q26534 , CATL_SCHMA , T;
DR P43234 , CATO_HUMAN , T; Q8BM88 , CATO_MOUSE , T;
DR P25326 , CATS_BOVIN , T; Q8HY81 , CATS_CANLF , T;
DR P25774 , CATS_HUMAN , T; O70370 , CATS_MOUSE , T;
DR Q02765 , CATS_RAT , T; Q8HY82 , CATS_SAIBB , T;
DR O91466 , CATV_GVCPM , T; Q9PYY5 , CATV_GVXN , T;
DR P25783 , CATV_NPVAC , T; Q80LP4 , CATV_NPVAH , T;
DR Q91CL9 , CATV_NPVAP , T; P41721 , CATV_NPVBM , T;
DR Q9YWK4 , CATV_NPVBS , T; Q6VTL7 , CATV_NPVCD , T;
DR P41715 , CATV_NPVCF , T; Q91GE3 , CATV_NPVEP , T;
DR Q9WGE0 , CATV_NPVHC , T; Q9YMP9 , CATV_NPVLD , T;
DR Q8QLK1 , CATV_NPVMC , T; O10364 , CATV_NPVOP , T;
DR Q8B9D5 , CATV_NPVR1 , T; Q9J8B9 , CATV_NPVSE , T;
DR Q91BH1 , CATV_NPVST , T; V5LU01 , CEP01_AMBAR, T;
DR Q9FGR9 , CEP1_ARATH , T; Q9STL4 , CEP2_ARATH , T;
DR Q9STL5 , CEP3_ARATH , T; Q54TR1 , CFAD_DICDI , T;
DR P82474 , CPGP2_ZINOF, T; O45734 , CPL1_CAEEL , T;
DR Q01957 , CPP1_ENTH1 , T; Q01958 , CPP2_ENTH1 , T;
DR P36184 , CPP3_ENTH1 , T; P25807 , CPR1_CAEEL , T;
DR Q9VN93 , CPR1_DROME , T; P43507 , CPR3_CAEEL , T;
DR P43508 , CPR4_CAEEL , T; P43509 , CPR5_CAEEL , T;
DR P43510 , CPR6_CAEEL , T; Q86GF7 , CRUST_PANBO, T;
DR Q54QD9 , CTSB_DICDI , T; P25803 , CYSEP_PHAVU, T;
DR O65039 , CYSEP_RICCO, T; P12412 , CYSEP_VIGMU, T;
DR P04988 , CYSP1_DICDI, T; P19092 , CYSP1_HAECO, T;
DR P13277 , CYSP1_HOMAM, T; P25249 , CYSP1_HORVU, T;
DR P35591 , CYSP1_LEIPI, T; Q10716 , CYSP1_MAIZE, T;
DR Q7XR52 , CYSP1_ORYSJ, T; P25802 , CYSP1_OSTOS, T;
DR P32954 , CYSP1_VASCU, T; P04989 , CYSP2_DICDI, T;
DR P25793 , CYSP2_HAECO, T; P25782 , CYSP2_HOMAM, T;
DR P25250 , CYSP2_HORVU, T; Q05094 , CYSP2_LEIPI, T;
DR Q10717 , CYSP2_MAIZE, T; P32955 , CYSP2_VASCU, T;
DR Q23894 , CYSP3_DICDI, T; P25784 , CYSP3_HOMAM, T;
DR Q40143 , CYSP3_SOLLC, T; P32956 , CYSP3_VASCU, T;
DR P25251 , CYSP4_BRANA, T; P54639 , CYSP4_DICDI, T;
DR P32957 , CYSP4_VASCU, T; P54640 , CYSP5_DICDI, T;
DR Q94503 , CYSP6_DICDI, T; Q94504 , CYSP7_DICDI, T;
DR P20721 , CYSPL_SOLLC, T; A1KXI0 , CYSP_BLOTA , T;
DR P43156 , CYSP_HEMSP , T; P25804 , CYSP_PEA , T;
DR P43157 , CYSP_SCHJA , T; P25792 , CYSP_SCHMA , T;
DR P22497 , CYSP_THEPA , T; P14658 , CYSP_TRYBB , T;
DR P25779 , CYSP_TRYCR , T; Q8RVL2 , DEK1_ARATH , T;
DR Q8RVL1 , DEK1_MAIZE , T; Q6ZFZ4 , DEK1_ORYSJ , T;
DR A5YVK8 , ERVA_TABDI , T; P60994 , ERVB_TABDI , T;
DR P83654 , ERVC1_TABDI, T; A8DS38 , ERVC2_TABDI, T;
DR P25805 , FPC1_PLAF7 , T; Q8I6U4 , FPC2A_PLAF7, T;
DR Q8I6U5 , FPC2B_PLAF7, T; Q8IIL0 , FPC3_PLAF7 , T;
DR Q54ME1 , GMSA_DICDI , T; P25775 , LMCPA_LEIME, T;
DR P36400 , LMCPB_LEIME, T; P83443 , MDO1_ANAMC , T;
DR P84346 , MEX1_JACME , T; P84347 , MEX2_JACME , T;
DR B2LSD2 , MUCIN_MUCPR, T; P25776 , ORYA_ORYSJ , T;
DR P25777 , ORYB_ORYSJ , T; P25778 , ORYC_ORYSJ , T;
DR P00784 , PAPA1_CARPA, T; P14080 , PAPA2_CARPA, T;
DR P10056 , PAPA3_CARPA, T; P05994 , PAPA4_CARPA, T;
DR Q48543 , PEPC_LACDL , T; Q10744 , PEPC_LACHE , T;
DR Q9CEG3 , PEPC_LACLA , T; Q04723 , PEPC_LACLC , T;
DR Q928V0 , PEPC_LISIN , T; O69192 , PEPC_LISMO , T;
DR Q56115 , PEPC_STRTR , T; P94870 , PEPE_LACHE , T;
DR P94869 , PEPG_LACDL , T; P16311 , PEPT1_DERFA, T;
DR P08176 , PEPT1_DERPT, T; P25780 , PEPT1_EURMA, T;
DR P94868 , PEPW_LACDL , T; P46102 , PVP1_PLAVN , T;
DR P43296 , RD19A_ARATH, T; P43295 , RD19B_ARATH, T;
DR Q9SUL1 , RD19C_ARATH, T; Q8VYS0 , RD19D_ARATH, T;
DR P43297 , RD21A_ARATH, T; Q9FMH8 , RD21B_ARATH, T;
DR Q9LT78 , RD21C_ARATH, T; Q94B08 , RDL1_ARATH , T;
DR Q9LT77 , RDL2_ARATH , T; Q9LXW3 , RDL3_ARATH , T;
DR Q7F3A8 , REP1_ORYSJ , T; Q7GDU7 , REPA_ORYSJ , T;
DR Q9FJ47 , SAG12_ARATH, T; A2XQE8 , SAG39_ORYSI, T;
DR Q7XWK5 , SAG39_ORYSJ, T; Q9TY96 , SERA6_PLAF7, T;
DR Q26015 , SERA6_PLAFA, T; P21381 , THPA_THADA , T;
DR P25806 , TPR_PORGI , T; A0A068CNX1, VANSY_GLEHE, T;
DR A0A0F7G352, VANSY_VANPL, T; Q197D6 , VF224_IIV3 , T;
DR Q91FU7 , VF224_IIV6 , T; P42666 , VX1_PLAVS , T;
DR O65493 , XCP1_ARATH , T; Q9LM66 , XCP2_ARATH , T;
DR P20728 , CAL1_CALGI , P; P06815 , CAN1_RABIT , P;
DR P43367 , CAN2_PIG , P; P06814 , CAN2_RABIT , P;
DR P81494 , CATB_COTJA , P; Q09093 , CATL1_FASHE, P;
DR P25773 , CATL1_FELCA, P; P80342 , CATL2_FASHE, P;
DR P80532 , CATL3_FASHE, P; P80528 , CATL4_FASHE, P;
DR P80533 , CATL9_FASHE, P; P80529 , CYSB_FASHE , P;
DR Q06544 , CYSP3_OSTOS, P; P33403 , CYSP_TRIFO , P;
DR P33404 , CYSP_TRIVA , P; P29184 , HP29_SARPE , P;
DR P22442 , KARA_BROPL , P; P83447 , MDO2_ANAMC , P;
DR P05993 , PAPA5_CARPA, P; P16312 , PEPT1_DERMI, P;
DR P84789 , PHIG1_PHIGI, P;
DR Q6MZZ7 , CAN13_HUMAN, N; Q9Y6Q1 , CAN6_HUMAN , N;
DR O35646 , CAN6_MOUSE , N; O88501 , CAN6_RAT , N;
DR Q9Y6W3 , CAN7_HUMAN , N; Q9R1S8 , CAN7_MOUSE , N;
DR A0FKG7 , CAN7_PIG , N; Q9VXH6 , CANC_DROME , N;
DR F4HVZ1 , CATB1_ARATH, N; Q26563 , CATC_SCHMA , N;
DR Q94715 , CATL3_PARTE, N; Q9JL96 , CATM_MOUSE , N;
DR Q9QZE3 , CATQ_RAT , N; Q9JIA9 , CATR_MOUSE , N;
DR Q8V5U0 , CATV_NPVHZ , N; Q9TST1 , CATW_FELCA , N;
DR P56202 , CATW_HUMAN , N; P56203 , CATW_MOUSE , N;
DR G5EGP8 , CATZ1_CAEEL, N; P05689 , CATZ_BOVIN , N;
DR Q9UBR2 , CATZ_HUMAN , N; Q9WUU7 , CATZ_MOUSE , N;
DR Q9R1T3 , CATZ_RAT , N; P82473 , CPGP1_ZINOF, N;
DR P25781 , CYSP_THEAN , N; Q8IIJ9 , DPAP1_PLAF7, N;
DR P0C0P9 , ECPA_STAEP , N; Q5HKF6 , ECPA_STAEQ , N;
DR P0C0Q0 , ECPA_STAES , N; P22895 , P34_SOYBN , N;
DR Q1EIQ3 , PEPT1_PSOOV, N; Q9SUT0 , RDL4_ARATH , N;
DR Q9SUS9 , RDL5_ARATH , N; F4JNL3 , RDL6_ARATH , N;
DR Q9TY95 , SERA5_PLAF7, N; P69193 , SERA5_PLAFD, N;
DR P69192 , SERA5_PLAFG, N; Q6YD92 , SILIC_PETFI, N;
DR Q2FZL3 , SSPB_STAA8 , N; Q5HH36 , SSPB_STAAC , N;
DR Q99V46 , SSPB_STAAM , N; Q7A6A7 , SSPB_STAAN , N;
DR Q6GI35 , SSPB_STAAR , N; Q6GAG5 , SSPB_STAAS , N;
DR P0C1S6 , SSPB_STAAU , N; Q8NX99 , SSPB_STAAW , N;
DR Q2G2R8 , SSPP_STAA8 , N; Q5HEL3 , SSPP_STAAC , N;
DR P65825 , SSPP_STAAM , N; P65826 , SSPP_STAAN , N;
DR Q6GFE8 , SSPP_STAAR , N; Q6G824 , SSPP_STAAS , N;
DR P81297 , SSPP_STAAU , N; Q8NVS9 , SSPP_STAAW , N;
DR Q80UB0 , TEST2_MOUSE, N; P15242 , TEST2_RAT , N;
DR P90850 , YCF2E_CAEEL, N;
DR Q2UPB9 , ACLI_ASPOR , F; Q3SYX3 , CB042_BOVIN, F;
DR Q9NWW7 , CB042_HUMAN, F; Q4R907 , CB042_MACFA, F;
DR Q8R3C1 , CB042_MOUSE, F; Q9NUG4 , CCM2L_HUMAN, F;
DR Q7VEN1 , COBD_MYCBO , F; P9WP92 , COBD_MYCTO , F;
DR Q9NZV1 , CRIM1_HUMAN, F; F1R520 , CSTN1_DANRE, F;
DR P52375 , HEPA_HHV6U , F; Q5DM57 , IF172_CHLRE, F;
DR Q8AXC6 , KIT_TAKRU , F; P82139 , RK10_SPIOL , F;
DR C0HK69 , SCXD_CENLI , F; G5EFD5 , UNC71_CAEEL, F;
DR Q4VM08 , VM3VA_MACLB, F;
3D 1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4;
3D 1BQI; 1BY8; 1CB5; 1CPJ; 1CQD; 1CS8; 1CSB; 1CTE; 1CVZ; 1EWL; 1EWM; 1EWO;
3D 1EWP; 1F29; 1F2A; 1F2B; 1F2C; 1FH0; 1GCB; 1GEC; 1GMY; 1HUC; 1ICF; 1ITO;
3D 1IWD; 1JQP; 1K3B; 1KFU; 1KFX; 1KHP; 1KHQ; 1M6D; 1ME3; 1ME4; 1MEG; 1MEM;
3D 1MHW; 1MS6; 1NB3; 1NB5; 1NL6; 1NLJ; 1NPZ; 1NQC; 1O0E; 1PAD; 1PBH; 1PCI;
3D 1PE6; 1PIP; 1POP; 1PPD; 1PPN; 1PPO; 1PPP; 1Q6K; 1QDQ; 1S4V; 1SNK; 1SP4;
3D 1STF; 1THE; 1TL9; 1TLO; 1TU6; 1U9Q; 1U9V; 1U9W; 1U9X; 1VSN; 1YAL; 1YK7;
3D 1YK8; 1YT7; 1YVB; 1ZCM; 1ZIV; 2ACT; 2AIM; 2ARY; 2AS8; 2ATO; 2AUX; 2AUZ;
3D 2BDL; 2BDZ; 2CIO; 2DC6; 2DC7; 2DC8; 2DC9; 2DCA; 2DCB; 2DCC; 2DCD; 2DJF;
3D 2DJG; 2DZY; 2DZZ; 2E00; 2E01; 2E02; 2F1G; 2F7D; 2FO5; 2FQ9; 2FRA; 2FRQ;
3D 2FT2; 2FTD; 2FUD; 2FYE; 2G6D; 2G7Y; 2G8E; 2G8J; 2GHU; 2H7J; 2HH5; 2HHN;
3D 2HXZ; 2IPP; 2NQA; 2NQG; 2NQI; 2OP3; 2OUL; 2OZ2; 2P0R; 2PAD; 2PBH; 2PNS;
3D 2PRE; 2R6N; 2R9C; 2R9F; 2R9M; 2R9N; 2R9O; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2;
3D 2YJ8; 2YJ9; 2YJB; 2YJC; 3AI8; 3BC3; 3BCN; 3BPF; 3BPM; 3BWK; 3C9E; 3E1Z;
3D 3H6S; 3H7D; 3H89; 3H8B; 3H8C; 3HD3; 3HHA; 3HWN; 3I06; 3IMA; 3IUT; 3K9M;
3D 3KFQ; 3KKU; 3KSE; 3KW9; 3KWB; 3KWZ; 3KX1; 3LFY; 3LXS; 3N3G; 3N4C; 3O0U;
3D 3O1G; 3OF8; 3OF9; 3OVX; 3OVZ; 3PBH; 3PDF; 4AXL; 4AXM; 4BPV; 4BQV; 4BS5;
3D 4BS6; 4BSQ; 4CDC; 4CDD; 4CDE; 4CDF; 4DMX; 4DMY; 4KLB; 4MZO; 4MZS; 4N79;
3D 4N8W; 4OEL; 4OEM; 4P6E; 4P6G; 4PAD; 4PI3; 4QH6; 4X6H; 4X6I; 4X6J; 4XUI;
3D 4YV8; 4YVA; 5EF4; 5EGW; 5F02; 5JT8; 5MAE; 5MAJ; 5MBL; 5MBM; 5MQY; 5PAD;
3D 5T6U; 5TDI; 5TUN; 5VCN; 5VCO; 5VPG; 5VPH; 5VPK; 5VPL; 6ASH; 6AY2; 6BJD;
3D 6BKI; 6BKJ; 6CZK; 6EZP; 6EZX; 6F06; 6H8T; 6HGY; 6JW9; 6MIS; 6N3S; 6O2X;
3D 6OKJ; 6P3Q; 6P4E; 6PAD; 6PXF; 6QBS; 6QL8; 6QLM; 6QLW; 6QLX; 6QM0; 6TCX;
3D 6UX6; 6Y6L; 6YCB; 6YCC; 6YCD; 6YYN; 6YYO; 6YYP; 6YYQ; 6YYR; 7EI0; 7JUJ;
3D 7NXL; 7NXM; 7PCK; 7QBL; 7QBM; 7QBN; 7QBO; 7QGW; 7QKB; 7QKC; 7QKD; 7S18;
3D 7S19; 7V5L; 7W33; 7W34; 7W7O; 7X79; 7XF9; 7Z3T; 7Z58; 7ZS7; 7ZVF; 7ZXA;
3D 8A4U; 8A4V; 8A4W; 8A4X; 8A5B; 8AHV; 8B4F; 8B4T; 8B5F; 8C3D; 8C77; 8GT0;
3D 8GT7; 8GX2; 8GX3; 8OFA; 8OZA; 8PCH; 8PRX; 8QKB; 9PAP;
PR PRU10088;
DO PDOC00126;
//