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ENZYME

ENZYME entry: EC 1.14.17.1

Accepted Name
dopamine beta-monooxygenase
Alternative Name(s)
(3,4-dihydroxyphenethylamine)beta-monooxygenase
dopamine beta-hydroxylase
Reaction catalysed
dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical
Comment(s)
  • A copper protein.
  • The enzyme, found in animals, binds two copper ions with distinct roles during catalysis.
  • Stimulated by fumarate.
  • Formerly EC 1.14.2.1.
Cross-references
BRENDA1.14.17.1
EC2PDB1.14.17.1
ExplorEnz1.14.17.1
PRIAM enzyme-specific profiles1.14.17.1
KEGG Ligand Database for Enzyme Nomenclature1.14.17.1
IUBMB Enzyme Nomenclature1.14.17.1
IntEnz1.14.17.1
MEDLINEFind literature relating to 1.14.17.1
MetaCyc1.14.17.1
Rhea expert-curated reactions1.14.17.1
UniProtKB/Swiss-Prot
P15101, DOPO_BOVINQ68CI2, DOPO_CANLFQ9XTA0, DOPO_HORSE
P09172, DOPO_HUMANQ64237, DOPO_MOUSEQ05754, DOPO_RAT

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