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ENZYME

ENZYME entry: EC 1.3.1.77

Accepted Name
anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]
Alternative Name(s)
ANR
anthocyanidin reductase
Reaction catalysed
  • a (2R,3R)-flavan-3-ol + 2 NAD(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH
  • a (2R,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
Comment(s)
  • The enzyme participates in the flavonoid biosynthesis pathway found in plants.
  • It catalyzes the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins.
  • While the enzyme from the legume Medicago truncatula can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana uses only NADPH.
  • Also, while the substrate preference of the M. truncatula is cyanidin>pelargonidin>delphinidin, the reverse preference is found with the Arabidopsis enzyme. cf. EC 1.3.1.112.
Cross-references
BRENDA1.3.1.77
EC2PDB1.3.1.77
ExplorEnz1.3.1.77
PRIAM enzyme-specific profiles1.3.1.77
KEGG Ligand Database for Enzyme Nomenclature1.3.1.77
IUBMB Enzyme Nomenclature1.3.1.77
IntEnz1.3.1.77
MEDLINEFind literature relating to 1.3.1.77
MetaCyc1.3.1.77
Rhea expert-curated reactions1.3.1.77
UniProtKB/Swiss-Prot
Q9SEV0, BAN_ARATH

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