PROSITE entry PS01206

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General information about the entry

Entry name [info]	ASC
Accession [info]	PS01206
Entry type [info]	PATTERN
Date [info]	01-NOV-1997 CREATED; 01-APR-2006 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00926

Name and characterization of the entry

Description [info]	Amiloride-sensitive sodium channels signature.
Pattern [info]	Y-x(2)-[EQTFPMSI]-x-C-x(3)-C-x-[QTAVKS]-x(2)-[LIVMT]-[LIVMSAQ]-x(2)-C-x- C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	70 in 70 different sequences
Number of true positive hits	70 in 70 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	92.11 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

70 sequences

ASI1A_DANRE (Q708S7), ASI1B_DANRE (Q708S8), ASI1C_DANRE (Q708S6),

ASI4A_DANRE (Q708S4), ASI4B_DANRE (Q708S3), ASIC1_CAEEL (O01635), 
ASIC1_CHICK (Q1XA76), ASIC1_HUMAN (P78348), ASIC1_MOUSE (Q6NXK8), 
ASIC1_OPSTA (Q7T1N4), ASIC1_RAT   (P55926), ASIC2_CAEEL (Q22851), 
ASIC2_DANRE (Q708S5), ASIC2_HUMAN (Q16515), ASIC2_MOUSE (Q925H0), 
ASIC2_RAT   (Q62962), ASIC3_HUMAN (Q9UHC3), ASIC3_MOUSE (Q6X1Y6), 
ASIC3_RAT   (O35240), ASIC4_HUMAN (Q96FT7), ASIC4_MOUSE (Q7TNS7), 
ASIC4_RAT   (Q9JHS6), DEG1_CAEEL  (P24585), DEL1_CAEEL  (Q19038), 
FANA_CORAP  (Q25011), MEC10_CAEBR (Q60NC0), MEC10_CAEEL (P34886), 
MEC4_CAEBR  (Q17298), MEC4_CAEEL  (P24612), NACH_DROAN  (O61370), 
NACH_DROME  (O61365), NACH_DROVI  (Q9NJP2), PPK11_DROME (Q9VL84), 
SCNNA_ANOCA (H9GBX2), SCNNA_BOVIN (P55270), SCNNA_CAVPO (Q9R1N2), 
SCNNA_CHICK (Q92075), SCNNA_HUMAN (P37088), SCNNA_MOUSE (Q61180), 
SCNNA_NEOFS (H1AFJ5), SCNNA_PANTR (H2Q5A1), SCNNA_PELSI (K7GET2), 
SCNNA_RABIT (O97741), SCNNA_RAT   (P37089), SCNNA_XENLA (P51167), 
SCNNB_AQUCT (Q9W754), SCNNB_BOVIN (A5D7U4), SCNNB_CANLF (Q95165), 
SCNNB_HUMAN (P51168), SCNNB_MOUSE (Q9WU38), SCNNB_NEOFS (H1AFJ6), 
SCNNB_RABIT (O97742), SCNNB_RAT   (P37090), SCNNB_SHEEP (O62816), 
SCNNB_XENLA (P51169), SCNNC_XENLA (O13262), SCNND_HUMAN (P51172), 
SCNND_PANTR (O46547), SCNNG_BOVIN (F1MJW3), SCNNG_HUMAN (P51170), 
SCNNG_MOUSE (Q9WU39), SCNNG_NEOFS (H1AFJ7), SCNNG_PANTR (H2QAR5), 
SCNNG_PELSI (K7FSQ4), SCNNG_RABIT (Q28738), SCNNG_RAT   (P37091), 
SCNNG_XENLA (P51171), SCNNH_XENLA (O13263), UN105_CAEEL (Q09274), 
UNC8_CAEEL  (Q21974)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

6 sequences

ASIC5_HUMAN (Q9NY37), ASIC5_MOUSE (Q9R0Y1), ASIC5_RAT   (Q9R0W5),

DEL10_CAEEL (Q10025), PPK19_DROME (Q9VAJ3), PPK28_DROME (Q86LG1)

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PDB
[Detailed view]

28 PDB

2QTS; 3IJ4; 3S3W; 3S3X; 4FZ0; 4FZ1; 4NTW; 4NTX; 4NTY; 4NYK; 5WKU; 5WKV; 5WKX; 5WKY; 6AVE; 6BQN; 6CMC; 6L6I; 6L6N; 6L6P; 6VTK; 6VTL; 6WTH; 6X9H; 7CFS; 7CFT; 7LIE; 7RNN
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