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PROSITE entry PS00131


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General information about the entry

Entry name [info] CARBOXYPEPT_SER_SER
Accession [info] PS00131
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-FEB-2003 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00122
Associated ProRule [info] PRU10074

Name and characterization of the entry

Description [info] Serine carboxypeptidases, serine active site.
Pattern [info] 
[LIVM]-x-[GSTA]-E-S-Y-[AG]-[GS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 172 in 172 different sequences
Number of true positive hits 164 in 164 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 56
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 95.35 %
Recall (true positives / (true positives + false negatives)) 74.55 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 164 sequences 

ACUI_ASPA1  (A0A1L9WN42), ATG42_YEAST (P38109), CBP1_HORVU  (P07519), 

CBP1_ORYSJ  (P37890), CBP21_HORVU (P55747), CBP22_HORVU (P55748), 
CBP23_HORVU (P52711), CBP2_HORVU  (P08818), CBP2_WHEAT  (P08819), 
CBP3_HORVU  (P21529), CBP3_ORYSJ  (P37891), CBP3_WHEAT  (P11515), 
CBPX_ORYSJ  (P52712), CBPYA_AJECG (C0NX46), CBPYA_AJECN (A6RGA0), 
CBPYA_AJEDR (C5GEU5), CBPYA_ARTBC (D4AZ71), CBPYA_ARTGP (E4USS9), 
CBPYA_ARTOC (C5FWJ1), CBPYA_ASPCL (A1CUJ5), CBPYA_ASPFN (B8NXS9), 
CBPYA_ASPFU (Q5VJG9), CBPYA_ASPNC (A5AB21), CBPYA_ASPOR (Q2TYA1), 
CBPYA_ASPTN (Q0CSD3), CBPYA_BLAGS (C5K1Y9), CBPYA_BOTFB (A6RUD7), 
CBPYA_CHAGB (Q2H9G6), CBPYA_COCP7 (C5P212), CBPYA_COLGM (E3QR43), 
CBPYA_EMENI (Q96VC4), CBPYA_FUSV7 (C7YQJ2), CBPYA_LEPMJ (E5A7I6), 
CBPYA_NEOFI (A1DP75), CBPYA_NEUCR (Q7RXW8), CBPYA_PARBA (C1GXD8), 
CBPYA_PARBD (C1GG77), CBPYA_PARBP (C0SGX7), CBPYA_PENRW (B6HPP6), 
CBPYA_PHANO (Q0V1R1), CBPYA_PODAN (B2AWD5), CBPYA_PYRO7 (A4RPY8), 
CBPYA_PYRTR (B2WKF1), CBPYA_SCLS1 (A7F4H5), CBPYA_SORMK (D1ZG13), 
CBPYA_TALMQ (B6QAN5), CBPYA_TALSN (B8M044), CBPYA_TRIEQ (B8XGR4), 
CBPYA_TRIRU (Q5J6J0), CBPYA_TRITO (A5YCB8), CBPYA_TRIVH (D4DLI1), 
CBPYA_UNCRE (C4JNM2), CBPYB_ARTBC (D4ANB6), CBPY_CANAX  (P30574), 
CBPY_KOMPG  (P52710), CBPY_SCHPO  (O13849), CBPY_YEAST  (P00729), 
CPS1_PENJA  (P34946), CPVL_DICDI  (Q869Q8), CPVL_HUMAN  (Q9H3G5), 
CPVL_MOUSE  (Q9D3S9), CPVL_PONAB  (Q5RFE4), CPVL_RAT(Q4QR71), 
CTS11_CAEEL (P52717), CTS12_CAEEL (P52715), CTS31_CAEEL (P52716), 
CTS32_CAEEL (P52714), CTS41_CAEEL (Q09991), DPP4_TRIRU  (Q5J6J3), 
KEX1_ARTBC  (D4B5L8), KEX1_ARTOC  (C5FTV7), KEX1_ASPCL  (A1CQL5), 
KEX1_ASPFC  (B0XQ16), KEX1_ASPFU  (Q4WTK9), KEX1_ASPNC  (A2QPW5), 
KEX1_ASPOR  (Q2UPI1), KEX1_CANGA  (Q6FTM9), KEX1_CLAL4  (C4Y8B4), 
KEX1_COLGM  (E3QDT3), KEX1_EMENI  (Q5BDJ6), KEX1_EREGS  (Q752M5), 
KEX1_FUSV7  (C7YRS6), KEX1_KLULA  (Q6CKK4), KEX1_KOMPG  (C4QZV7), 
KEX1_LEPMJ  (E5R540), KEX1_METRA  (E9ESM3), KEX1_NEOFI  (A1D3I1), 
KEX1_NEUCR  (Q1K722), KEX1_OGAPD  (E7R7R2), KEX1_PENRW  (B6H7A4), 
KEX1_PHANO  (Q0USX0), KEX1_PICPA  (O74702), KEX1_PODAN  (B2B762), 
KEX1_PYRTR  (B2W340), KEX1_SCLS1  (A7EYY7), KEX1_SORMK  (D1ZEM2), 
KEX1_TALMQ  (B6QQZ9), KEX1_TUBMM  (D5G4B1), KEX1_VANPO  (A7TLB3), 
KEX1_YARLI  (Q6CFP3), KEX1_YEAS2  (C7GWZ2), KEX1_YEAS8  (C8Z852), 
KEX1_YEASO  (E7NHF8), KEX1_YEAST  (P09620), NF314_NAEFO (P42661), 
PEPF_ASPNG  (P52718), PEPS_ARTBC  (D4AQA7), PEPS_ASPPH  (P52719), 
PPGB_BOVIN  (Q3MI05), PPGB_HUMAN  (P10619), PPGB_MOUSE  (P16675), 
RISC_HUMAN  (Q9HB40), RISC_MOUSE  (Q920A5), RISC_RAT(Q920A6), 
SCP1_MEDTR  (A0A0C3VJP4), SCP20_ARATH (Q8L7B2), SCP21_ARATH (Q9LSV8), 
SCP22_ARATH (Q1PF08), SCP23_ARATH (O82229), SCP24_ARATH (Q9M099), 
SCP25_ARATH (Q8L9Y0), SCP26_ARATH (Q9ZQQ0), SCP26_ORYSJ (Q5W727), 
SCP27_ARATH (Q9SFB5), SCP28_ARATH (Q8S8K6), SCP29_ARATH (Q949Q7), 
SCP30_ARATH (O23364), SCP31_ARATH (O04084), SCP32_ARATH (Q4PSY2), 
SCP33_ARATH (Q9LSM9), SCP34_ARATH (Q0WPR4), SCP35_ARATH (Q9LEY1), 
SCP39_ARATH (Q9SV02), SCP40_ARATH (Q0WRX3), SCP41_ARATH (Q9FH06), 
SCP42_ARATH (Q9FH05), SCP43_ARATH (Q84W27), SCP44_ARATH (Q9MAR8), 
SCP45_ARATH (Q93Y09), SCP46_ARATH (Q8VY01), SCP47_ARATH (Q9FFB0), 
SCP48_ARATH (Q56WF8), SCP49_ARATH (P32826), SCP51_ARATH (Q67Y83), 
SCP53_ARATH (Q9LXY6), SCP54_ARATH (Q9FFB2), SCPA_ARTBC  (D4AIF1), 
SCPA_TRITO  (B6V867), SCPA_TRIVH  (D4DD24), SCPB_ARTBC  (D4AP52), 
SCPB_ARTOC  (C5FGX1), SCPB_TRIRU  (Q5J6J2), SCPC_ARTBC  (D4AQ54), 
SCPD_ARTBC  (D4B0Q6), SCPE_ARTBC  (D4AZG9), SCPF_ARTBC  (D4ASE6), 
SCPL1_DICDI (Q54DY7), SCPL2_DICDI (Q54VW1), SPCA_ARTOC  (C5FW30), 
SPCA_TRIEQ  (A7UKV5), SPCA_TRIRU  (Q5J6J1), SXA2_SCHPO  (P32825), 
VCP_AEDAE   (P42660), VCP_APIME   (C9WMM5)
» more

UniProtKB/Swiss-Prot
False negative sequences		 56 sequences 

DAP4_PSEMX  (Q6F3I7), HNLS_SORBI  (P52708), KEX1_AJECN  (A6QX86), 

KEX1_AJEDR  (C5GC75), KEX1_ASPTN  (Q0CCR9), KEX1_BLAGS  (C5JN54), 
KEX1_CANAL  (Q5AFP8), KEX1_CANAW  (C4YTG0), KEX1_CANDC  (B9WJJ7), 
KEX1_CANTT  (C5MFP8), KEX1_CHAGB  (Q2GYB7), KEX1_COCP7  (C5P635), 
KEX1_COCPS  (E9CS37), KEX1_COPC7  (A8NYP0), KEX1_CRYGW  (E6R6G5), 
KEX1_DEBHA  (B5RUL7), KEX1_LACTC  (C5DLM9), KEX1_LODEL  (A5E751), 
KEX1_METAQ  (E9E1Z2), KEX1_PARBA  (C1GP85), KEX1_PARBD  (C1G2I2), 
KEX1_PARBP  (C0SGJ2), KEX1_PHYIT  (D0MVS1), KEX1_PICGU  (A5DAT0), 
KEX1_PUCGT  (E3L8A5), KEX1_PYRO7  (A4RE47), KEX1_SCHJY  (B6K7U7), 
KEX1_TALSN  (B8M719), KEX1_UNCRE  (C4JTD3), KEX1_USTMA  (Q4P8U8), 
KEX1_VERA1  (C9S688), KEX1_ZYGRC  (C5DT72), SCP10_ARATH (O64810), 
SCP11_ARATH (Q2V465), SCP12_ARATH (O81009), SCP13_ARATH (Q8H780), 
SCP14_ARATH (Q9C7D3), SCP15_ARATH (Q9C7D2), SCP16_ARATH (Q9C7D4), 
SCP17_ARATH (Q9C7D6), SCP18_ARATH (Q9C7Z9), SCP19_ARATH (Q8VZU3), 
SCP1_ARATH  (Q8RWJ6), SCP36_ARATH (Q9SV04), SCP37_ARATH (Q84WF0), 
SCP38_ARATH (Q9ZUG3), SCP3_ARATH  (Q9CAU1), SCP4_ARATH  (Q9CAU4), 
SCP50_ARATH (Q9M9Q6), SCP52_ARATH (Q8S8P0), SCP5_ARATH  (Q9CAU2), 
SCP6_ARATH  (Q9CAU0), SCP7_ARATH  (Q9SQX6), SCP8_ARATH  (Q8RUW5), 
SCP9_ARATH  (O64811), SCPL2_ARATH (Q9CAU3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

CBPX_PEA(Q41005), PEP1_ASPNG  (P55749)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			8 sequences
			


			
CAPSD_TTVV9 (Q9DUC4), CO4A3_HUMAN (Q01955), COMB_STRPN  (P36498), 

			
COMB_STRR6  (P59654), KT3K_ENTFD  (Q3XZZ9), RA213_ARATH (Q9LM15), 
SYTC_CAEEL  (P52709), T4149_TANPA (X2ESR4)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			18 PDB
			


			1AC5; 1BCR; 1BCS; 1IVY; 1WHS; 1WHT; 1WPX; 1YSC; 3SC2; 4AZ0; 4AZ3; 4CI9; 
			
				4CIA; 4CIB; 4MWS; 4MWT; 6WIA; 7KDV
			
			

			» more