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PROSITE entry PS00287


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General information about the entry

Entry name [info] CYSTATIN
Accession [info] PS00287
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00259

Name and characterization of the entry

Description [info] Cysteine proteases inhibitors signature.
Pattern [info]
[GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-{S}-
[LIVMFYA]-[DENQKRHSIV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 129 in 121 different sequences
Number of true positive hits 111 in 103 different sequences
Number of 'unknown' hits 0
Number of false positive hits 18 in 18 different sequences
Number of false negative sequences 47
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 86.05 %
Recall (true positives / (true positives + false negatives)) 70.25 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
103 sequences

CPI1_PIG(P35479), CPI2_BRUMA  (A0A0K0IP23), CST10_MOUSE (Q9JM84), 
CYS17_PLARH (A0A6B9L8T7), CYS1_ORNMO  (Q6QZV5), CYS2_ORNMO  (Q6QD55), 
CYT11_ORYSJ (Q6K309), CYT12_ORYSJ (Q0JNR2), CYT1_ARATH  (Q945Q1), 
CYT1_CROAD  (J3RYX9), CYT1_HORVU  (Q9LEI7), CYT1_MAIZE  (P31726), 
CYT1_MOUSE  (P35175), CYT1_ORYSJ  (P09229), CYT2_ARATH  (Q8L5T9), 
CYT2_CROAD  (J3SE80), CYT2_MOUSE  (P35174), CYT2_ORYSJ  (P20907), 
CYT3_ARATH  (Q41906), CYT3_MOUSE  (P35173), CYT6_ARATH  (Q8H0X6), 
CYT6_ORYSJ  (Q10Q46), CYT7_ARATH  (Q8LC76), CYT7_ORYSJ  (Q10Q47), 
CYT8_ORYSJ  (Q10J94), CYTA1_DICDI (Q65YR8), CYTA1_PIG   (Q28988), 
CYTA5_PIG   (Q28986), CYTA8_PIG   (Q28987), CYTA_BOVIN  (P80416), 
CYTA_FELCA  (Q8WNR9), CYTA_HELAN  (Q10992), CYTA_HUMAN  (P01040), 
CYTA_MOUSE  (P56567), CYTA_RAT(P01039), CYTA_SARPE  (P31727), 
CYTB_BOVIN  (P25417), CYTB_GORGO  (Q76LA0), CYTB_HELAN  (Q10993), 
CYTB_HUMAN  (P04080), CYTB_MACFU  (Q862Z5), CYTB_MOUSE  (Q62426), 
CYTB_OPLFA  (J7FQE8), CYTB_PANPA  (P60575), CYTB_PANTR  (Q8I030), 
CYTB_PIG(Q29290), CYTB_PONPY  (P60576), CYTB_RAT(P01041), 
CYTB_SHEEP  (Q10994), CYTC_BOVIN  (P01035), CYTC_HUMAN  (P01034), 
CYTC_MACMU  (O19092), CYTC_MOUSE  (P21460), CYTC_PAROL  (B2Z450), 
CYTC_RAT(P14841), CYTC_SAISC  (O19093), CYTD_HUMAN  (P28325), 
CYTI_VIGUN  (Q06445), CYTL2_IXOSC (B7PKZ1), CYTLG_IXOSC (B7PKZ2), 
CYTL_DROME  (P23779), CYTL_IXOSC  (Q8MVB6), CYTL_TACTR  (Q7M429), 
CYTM_HUMAN  (Q15828), CYTM_SOLTU  (P37842), CYTN_HUMAN  (P01037), 
CYTS_HUMAN  (P01036), CYTS_RAT(P19313), CYTT_HUMAN  (P09228), 
CYTX_BOVIN  (P35478), CYTX_ONCVO  (P22085), CYT_BITAR   (P08935), 
CYT_BITGA   (Q6T6T4), CYT_CHICK   (P01038), CYT_CHIGU   (B1P1J3), 
CYT_COTJA   (P81061), CYT_CRYNI   (E3P6P1), CYT_CYPCA   (P35481), 
CYT_MICIK   (E3P6P3), CYT_NAJKA   (E3P6P4), CYT_NOTSC   (E3P6P2), 
CYT_ONCKE   (Q98967), CYT_ONCMY   (Q91195), CYT_OXYMI   (E3P6N5), 
CYT_OXYSC   (E3P6N6), CYT_PSEAU   (E3P6N8), CYT_PSEPO   (E3P6N7), 
CYT_PSETE   (E3P6N4), CYT_SOLTU   (Q03196), EPI2B_PHYIN (A1L017), 
EPI2B_PHYIT (D0NBV3), EPIC1_PHYIN (A1L015), EPIC1_PHYIT (D0NBV1), 
EPIC4_PHYIN (A1L019), EPIC4_PHYIT (D0MSS2), KNG1_BOVIN  (P01044), 
KNG1_HUMAN  (P01042), KNG1_MOUSE  (O08677), KNG1_RAT(P08934), 
KNG2_BOVIN  (P01045), KNT1_RAT(P01048), KNT2_RAT(P08932), 
T71A_HADIN  (P0DXA0)
» more

UniProtKB/Swiss-Prot
False negative sequences
47 sequences

22P1_RAT(P22282), 22P2_RAT(P22283), CPI1_BRUMA  (P90698), 
CPI1_CAEEL  (G5EDZ9), CPI2_CAEEL  (G5ECM9), CST11_HUMAN (Q9H112), 
CST11_MOUSE (Q9D269), CST11_RAT   (Q8K5A3), CST12_MOUSE (Q9DAN8), 
CST12_RAT   (Q8VII2), CST13_MOUSE (Q80ZN5), CST14_MOUSE (Q8VII3), 
CST14_RAT   (Q8VIH8), CST15_BOVIN (Q2NKZ5), CST16_BOVIN (Q32KQ9), 
CST8_HUMAN  (O60676), CST8_MOUSE  (P32766), CST8_RAT(O88969), 
CST9L_HUMAN (Q9H4G1), CST9P_HUMAN (Q5W188), CST9_BOVIN  (Q29RH0), 
CST9_HUMAN  (Q5W186), CST9_MOUSE  (Q9Z0H6), CSTL1_HUMAN (Q9H114), 
CSTL1_MOUSE (Q80Y72), CYT10_ORYSI (A2XS65), CYT10_ORYSJ (P0C579), 
CYT1_ACTCC  (P86472), CYT1_ACTDE  (Q6TPK4), CYT3_ORYSJ  (Q6I570), 
CYT4_ARATH  (Q84WT8), CYT4_ORYSJ  (Q5N806), CYT5_ARATH  (Q41916), 
CYT5_ORYSJ  (Q0JGM8), CYT9_ORYSJ  (Q10Q48), CYTA2_DICDI (Q65YR7), 
CYTA3_DICDI (Q5R1U3), CYTB_PAROL  (B2Z449), CYTC_RABIT  (O97862), 
CYTF_HUMAN  (O76096), CYTF_MOUSE  (O89098), CYT_AUSSU   (E3P6N3), 
CYT_NAJAT   (P81714), HRG_HUMAN   (P04196), HRG_MOUSE   (Q9ESB3), 
HRG_RABIT   (Q28640), HRG_RAT (Q99PS8)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
5 sequences

CPI2_PIG(P80736), CYT1_CAPHI  (P84911), CYT2_CAPHI  (P84910), 
CYT3_WISFL  (P19864), CYT_SOYBN   (P25973)
» more

UniProtKB/Swiss-Prot
False positive sequences
18 sequences

ABCB4_DICDI (Q54W24), ACT_BACMT   (Q8KP10), ADPP_BACSU  (P54570), 
ATPE_ALCBS  (Q0VKX5), HEM1_CAMC5  (A7GYU7), KGUA_BACFN  (Q5L9N9), 
KGUA_BACFR  (Q64PY1), MRAY_ENTFA  (O07107), OADC_PSEMY  (A4XQ41), 
PP4R2_MOUSE (Q0VGB7), SASA_PROMP  (Q7V113), SIP5_COCIM  (Q1DZ34), 
SPXH_OCEIH  (Q8ERT3), SYM_METM5   (A4FZL1), SYM_METM7   (A6VIW5), 
SYM_METMP   (Q6M0E5), TICRR_DANRE (Q6DRL4), TOP1_MYCS2  (A0R5D9)
» more

PDB
[Detailed view]
41 PDB

1A67; 1A90; 1CEW; 1CYU; 1CYV; 1DVC; 1DVD; 1EQK; 1G96; 1GD3; 1GD4; 1N9J; 1NB3; 1NB5; 1R4C; 1RN7; 1ROA; 1STF; 1TIJ; 1YVB; 2OCT; 3GAX; 3K9M; 3KFQ; 3KSE; 3L0R; 3LH4; 3MWZ; 3PS8; 3QRD; 4LZI; 4N6L; 4N6M; 4N6N; 4N6O; 4N6V; 4TX4; 4ZM8; 6FK0; 8GT0; 8GT7
» more