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PROSITE entry PS00137


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General information about the entry

Entry name [info] SUBTILASE_HIS
Accession [info] PS00137
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
24-JAN-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10081

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, histidine active site.
Pattern [info]
H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_01 which contains 570'830 sequence entries.


Total number of hits 247 in 247 different sequences
Number of true positive hits 232 in 232 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 8
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 93.93 %
Recall (true positives / (true positives + false negatives)) 96.67 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
232 sequences

AEP_YARLI   (P09230), AEX5_CAEEL  (P91863), ALP2_ASPFC  (B0Y473), 
ALP2_ASPFU  (P87184), ALP_HAPCH   (P29118), ALP_HYPAT   (Q03420), 
ALP_LECPS   (Q68GV9), APRX_BACSU  (O31788), AQL1_THEAQ  (P08594), 
ASES_SARSR  (R4IR27), ASP_AERSO   (Q9L5A4), BLI4_CAEEL  (P51559), 
BLI_ONCVO   (A0A044RE18), BPRV_DICNO  (P42779), BPRX_DICNO  (P42780), 
C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), C5AP_STRP6  (Q5X9R0), 
C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), C5AP_STRPY  (P15926), 
CH901_DAVTA (B7ZK61), CL401_COCLU (B3V0K8), CRSP_ARATH  (Q9LNU1), 
CUDP_METAN  (P29138), ELYA_ALKAL  (P27693), ELYA_BACYA  (P20724), 
ELYA_HALH5  (P41363), ELYA_SHOCL  (P41362), EPIP_STAEP  (P30199), 
EXPR_XANCP  (P23314), FKPC1_CAEEL (O17798), FLS_FERPE   (Q93LQ6), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_BOVIN (Q28193), FURIN_HUMAN (P09958), 
FURIN_MOUSE (P23188), FURIN_RAT   (P23377), HLY_HALMT   (I3R794), 
HLY_NATA1   (P29143), ISP1_BACSU  (P11018), ISP6_SCHPO  (P40903), 
ISP_PAEPO   (P29139), ISP_SHOCL   (P29140), KEX1A_KLULA (P09231), 
KEX2_CANAW  (O13359), KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), 
MBTP1_CRIGR (Q9Z2A8), MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), 
MBTP1_RAT   (Q9WTZ3), MYCP2_MYCTU (O05458), MYCP3_MYCTU (O53695), 
MYCP4_MYCTU (I6YC58), MYCP5_MYCTU (O53945), NEC1_BOVIN  (Q9GLR1), 
NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), NEC1_MUSCO  (P63240), 
NEC1_RAT(P28840), NEC2_BOVIN  (Q9GLR0), NEC2_CAEEL  (G5ECN9), 
NEC2_DROME  (Q9VBC7), NEC2_HUMAN  (P16519), NEC2_MOUSE  (P21661), 
NEC2_PIG(Q03333), NEC2_PONAB  (Q5REC2), NEC2_RAT(P28841), 
NECA_HYDVU  (P29146), NECB_HYDVU  (P29145), NEP_NATMA   (Q5RLZ1), 
NISP_LACLL  (Q07596), ORYZ_ASPCL  (A1CIA7), ORYZ_ASPFC  (B0Y708), 
ORYZ_ASPFL  (P35211), ORYZ_ASPFN  (B8N106), ORYZ_ASPFU  (P28296), 
ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), ORYZ_NEOFI  (A1CWF3), 
P1P_LACLC   (P16271), P2P_LACLC   (P15293), P2P_LACPA   (Q02470), 
P3P_LACLS   (P15292), PCH18_PENCH (P9WEW6), PCH18_PENRB (P9WEW5), 
PCSK4_HUMAN (Q6UW60), PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), 
PCSK5_BRACL (Q9NJ15), PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), 
PCSK5_RAT   (P41413), PCSK6_HUMAN (P29122), PCSK6_RAT   (Q63415), 
PCSK7_HUMAN (Q16549), PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), 
PEN18_PENRB (Q9P8G3), PENC2_PENCI (Q9Y755), PEPC_ASPNG  (P33295), 
PLS_PYRFU   (P72186), POPC_MYXXD  (Q1DFT5), PRCA_NOSS1  (Q59149), 
PRCA_TRIV2  (P23916), PROA_VIBAL  (P16588), PRTB_YEAST  (P09232), 
PRTK_PARAQ  (P06873), PRTM_SHOC1  (Q99405), PRTR_PARAQ  (P23653), 
PRTS_SERMA  (P09489), PRTT_PARAQ  (P20015), PRTT_SERMA  (P29805), 
PSP3_SCHPO  (Q9UTS0), RM201_RHOMI (Q32ZM1), RRT12_YEAST (P25381), 
SBT24_ARATH (F4HYR6), SBT31_ARATH (F4JJH4), SBT33_ARATH (Q9MAP5), 
SBT34_ARATH (F4HPF1), SBT39_ARATH (Q9ZSB0), SBT3A_ARATH (Q9ZSB1), 
SBT3B_ARATH (Q1PDX5), SBT3C_ARATH (F4JJH5), SBT3G_ARATH (Q8GWX9), 
SBT41_ARATH (F4IG09), SBT51_ARATH (F4HSQ2), SBT61_ARATH (Q0WUG6), 
SEPR_THESR  (P80146), SMP1_MAGPO  (Q9Y778), SPAZ_ARTOA  (G1X8P8), 
SPAZ_ORBOL  (G3FNQ9), SPL1_ENCCU  (Q8SQJ3), SPM1_PYRO7  (P58371), 
SUB10_ARTBC (D4AQG0), SUB10_TRIVH (D4DIS6), SUB1_PLAF7  (Q8I0V0), 
SUB1_PLAFA  (O61142), SUB1_PLAFO  (W7K9M0), SUB1_PSED2  (L8G6I7), 
SUB2A_COCP7 (C5P6D1), SUB2C_COCP7 (C5NZ70), SUB2_ARTBC  (D4AZ75), 
SUB2_ARTBE  (Q64K35), SUB2_ARTGP  (E4UZP9), SUB2_ARTOC  (C5G168), 
SUB2_ARTOT  (Q8J0D8), SUB2_DEIRA  (Q9RYM8), SUB2_PLAF7  (Q8IHZ5), 
SUB2_PLAFA  (O97364), SUB2_PLAFP  (Q9Y008), SUB2_PSED2  (L8FSM5), 
SUB2_TRIEQ  (B6VA85), SUB2_TRIRU  (Q69F57), SUB2_TRITO  (B8XGQ5), 
SUB2_TRIVC  (Q5VJ76), SUB2_TRIVH  (D4DLI5), SUB3_PLAF7  (Q8I430), 
SUB3_PSED2  (L8GD75), SUB4B_COCP7 (C5NZT2), SUB5_ARTBC  (D4B194), 
SUB5_ARTBE  (Q64K32), SUB5_ARTGP  (E4V2L6), SUB5_ARTOC  (C5G1D1), 
SUB5_TRIEQ  (B6VA87), SUB5_TRIRU  (Q69F34), SUB5_TRITO  (B8XGQ8), 
SUB5_TRIVC  (Q5VJ73), SUB5_TRIVH  (D4D0F5), SUB6_ARTBC  (D4ALV9), 
SUB6_ARTBE  (Q64K31), SUB6_ARTGP  (E4V4J8), SUB6_ARTOC  (C5FQI3), 
SUB6_TRIEQ  (A1XIH0), SUB6_TRIRU  (Q9UW97), SUB6_TRISD  (A1XIH1), 
SUB6_TRISH  (Q8J077), SUB6_TRITO  (Q3ZEJ8), SUB6_TRIVC  (Q5VJ72), 
SUB6_TRIVH  (D4D5H3), SUB7B_COCP7 (C5PCX1), SUB7C_COCP7 (C5NZ69), 
SUB7_ARTBC  (D4APA9), SUB7_ARTBE  (Q64K36), SUB7_ARTGP  (E4V2V9), 
SUB7_ARTOC  (C5FJA5), SUB7_TRIEQ  (A1XIH3), SUB7_TRIRU  (Q8NID9), 
SUB7_TRISD  (A1XIH5), SUB7_TRITO  (A1XIH4), SUB7_TRIVC  (Q5VJ71), 
SUB7_TRIVH  (D4CZQ4), SUB7_TRIVO  (A1XIH6), SUB8_ARTBC  (D4AX50), 
SUB8_ARTOC  (C5FII2), SUB8_COCP7  (C5P4Z8), SUB8_TRIVH  (D4DKQ4), 
SUBB_LEDLE  (P29599), SUBC_BACLI  (P00780), SUBD_BACLI  (P00781), 
SUBE_BACSU  (P16396), SUBF_BACSU  (P16397), SUBN_BACNA  (P35835), 
SUBS_LEDLE  (P29600), SUBT_BACAM  (P00782), SUBT_BACPU  (P07518), 
SUBT_BACS9  (P28842), SUBT_BACSA  (P00783), SUBT_BACSU  (P04189), 
SUBT_GEOSE  (P29142), SUBV_BACSU  (P29141), TAGB_DICDI  (P54683), 
TAGC_DICDI  (Q23868), TAGD_DICDI  (Q8T9W1), THES_BACSJ  (Q45670), 
THET_THEVU  (P04072), TKSP_THEKO  (Q5JIZ5), TPP2_BOVIN  (A5PK39), 
TPP2_CAEEL  (Q09541), TPP2_DROME  (Q9V6K1), TPP2_HUMAN  (P29144), 
TPP2_MOUSE  (Q64514), TPP2_RAT(Q64560), TPP2_SCHPO  (Q9UT05), 
TPPII_ARATH (F4JVN6), WPRA_BACSU  (P54423), XPR6_YARLI  (P42781), 
YSP3_YEAST  (P25036)
» more

UniProtKB/Swiss-Prot
False negative sequences
8 sequences

NALP_NEIMB  (Q9JXM7), NALP_NEIMH  (E6MVD9), SBT1_LOTJA  (A9QY40), 
SBT3_LOTJA  (A9QY39), SBT4_LOTJA  (A9QY38), SBTS_LOTJA  (A9JQS7), 
SBT_MEDTR   (G7KEU7), SBT_PETHY   (A0A0M3R8G2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454), 
NVSP_ALIVI  (P83433), PRTE_HALME  (P28308), SP01_SCEBO  (Q10721), 
THEM_MALCI  (P13858)
» more

UniProtKB/Swiss-Prot
False positive sequences
15 sequences

ADCY8_HUMAN (P40145), ADCY8_MOUSE (P97490), ADCY8_RAT   (P40146), 
DGGGP_METTH (O27170), KTNB1_XENTR (Q6NVM2), PSBA3_GLOVI (Q7NH81), 
PSBA_ALETA  (Q9TM69), PSBA_AMPCA  (Q9BBC1), PSBA_AMPOP  (Q7HP56), 
PSBA_HETNI  (Q9MSC0), PSBA_HETPY  (Q9MSC1), PSBA_HETRO  (Q9MSC2), 
PSBA_HETTR  (Q9XQV1), PSBA_PROMC  (Q9TM72), TM241_MOUSE (Q3UME2)
» more

PDB
[Detailed view]
435 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN; 1SEL; 1SIB; 1SPB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN; 1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 3AFG; 3AJ8; 3AJ9; 3BGO; 3BX1; 3CNQ; 3CO0; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3HJR; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VSB; 3VYV; 3WHI; 3WQB; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4LVN; 4LVO; 4MZD; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5OX2; 5ROC; 5ROD; 5ROE; 5ROF; 5ROG; 5ROH; 5ROI; 5ROJ; 5ROK; 5ROL; 5ROM; 5RON; 5ROO; 5ROP; 5ROQ; 5ROR; 5ROS; 5ROT; 5ROU; 5ROV; 5ROW; 5ROX; 5ROY; 5ROZ; 5RP0; 5RP1; 5RP2; 5RP3; 5RP4; 5RP5; 5RP6; 5RP7; 5RP8; 5RP9; 5RPA; 5RPB; 5RPC; 5RPD; 5RPE; 5RPF; 5RPG; 5RPH; 5RPI; 5RPJ; 5RPK; 5RPL; 5RPM; 5RPN; 5RPO; 5RPP; 5RPQ; 5RPR; 5RPS; 5RPT; 5RPU; 5RPV; 5RPW; 5RPX; 5RPY; 5RPZ; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6DWQ; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6J43; 6K2P; 6K2R; 6K2S; 6K2T; 6K2V; 6K2W; 6K2X; 6K8M; 6KKF; 6LAW; 6MH6; 6N4U; 6O44; 6PAK; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR; 6PKS; 6PKT; 6PQ0; 6PQ4; 6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN; 6RUW; 6RVE; 6RVG; 6RZP; 6TXG; 6V8R; 6Y5S; 6Y5T; 6YD2; 6YD3; 6YD4; 6YD7; 6ZET; 6ZEU; 6ZEV; 7A68; 7A9F; 7A9K; 7A9M; 7AM3; 7AM4; 7AM5; 7AM6; 7AM7; 7AM8; 7BJ3; 7C0P; 7JSY; 7LCU; 7LN7; 7LPT; 7LPU; 7LPV; 7LQ8; 7LQ9; 7LQA; 7LQB; 7LQC; 7LTD; 7LTI; 7LTV; 7LU0; 7LU1; 7LU2; 7LU3; 7NJJ; 7NP7; 7NPR; 7NPS; 7NUY; 7NUZ; 7O1U; 7O1W; 7O1Y; 7O20; 7O22; 7QXY; 7QXZ; 7QY0; 7QY1; 7QY2; 7S4Z; 7SKX; 7SVY; 7SVZ; 7SW0; 7SW1; 7SW2; 7SW3; 7SW4; 7SW5; 7SW6; 7SW7; 7SW8; 7SW9; 7SWA; 7SWB; 7SWC; 7YZX; 8B4V; 8B4W; 8B4X; 8E52; 8E53; 8E7F; 8F05; 8F06; 8F07; 8FYO; 8FYP; 8FYQ; 8FYR; 8FYS; 8SDK; 8SOG; 8SOU; 8SOV; 8SPL; 8SQV
» more