ID   1.21.3.2
DE   Columbamine oxidase.
AN   Berberine synthase.
CA   2 columbamine + O(2) = 2 berberine + 2 H(2)O.
CF   Iron.
CC   -!- Oxidation of the O-methoxyphenol structure forms the methylenedioxy
CC       group of berberine.
CC   -!- Formerly EC 1.1.3.26.
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