NiceZyme View of ENZYME: EC 1.21.4.3
| Accepted Name |
|---|
| Sarcosine reductase.
|
| Reaction catalysed |
|---|
| Acetyl phosphate + methylamine + thioredoxin disulfide <=> N-methylglycine + phosphate + thioredoxin |
| Comment(s) |
|---|
- The reaction is observed only in the direction of sarcosine
reduction.
- The enzyme from Eubacterium acidaminophilum consists of subunits A,
B and C.
- Subunit B contains selenocysteine and a pyruvoyl group, and is
responsible for sarcosine binding and methylamine release.
- Subunit A, which also contains selenocysteine, is reduced by
thioredoxin, and is needed to convert the carboxymethyl group into a
ketene equivalent, in turn used by subunit C to produce acetyl
phosphate.
- Only subunit B distinguishes this enzyme from EC 1.21.4.2 and
EC 1.21.4.4.
|
| Cross-references |
|---|
| BRENDA | 1.21.4.3 |
| EC2PDB | 1.21.4.3 |
| PRIAM enzyme-specific profiles | 1.21.4.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.21.4.3 |
| IUBMB Enzyme Nomenclature | 1.21.4.3 |
| IntEnz | 1.21.4.3 |
| MEDLINE | Find literature relating to 1.21.4.3 |
| MetaCyc | 1.21.4.3 |
| UniProtKB/Swiss-Prot |
| P50972, GRDA1_EUBAC; | Q6LH20, GRDA1_PHOPR; | O32518, GRDA2_EUBAC; |
| Q6LH19, GRDA2_PHOPR; | A6TU46, GRDA_ALKMQ; | Q3A9J5, GRDA_CARHZ; |
| A7FTE0, GRDA_CLOB1; | A7GCV1, GRDA_CLOBL; | P52216, GRDA_CLOLI; |
| P26970, GRDA_CLOPU; | P26971, GRDA_CLOST; | Q67KE6, GRDA_SYMTH; |
| Q73PQ2, GRDA_TREDE; | P54935, GRDC_EUBAC; | Q47878, GRDD_EUBAC; |
| O86186, GRDF_EUBAC; | O86185, GRDG_EUBAC; |
|
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