Accepted Name |
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
|
Alternative Name(s) |
chondroitin glucuronyltransferase II |
Reaction catalysed |
- 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
- 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
|
Comment(s) |
- Involved in the biosynthesis of chondroitin and dermatan sulfate.
- The human chondroitin synthetase is a bifunctional
glycosyltransferase, which also has the EC 2.4.1.175 activity
required for the synthesis of the chondroitin sulfate disaccharide
repeats.
- Similar chondroitin synthase 'copolymerases' can be found in
Pasteurella multocida and Escherichia coli.
- There is also another human protein with apparently only the 3-beta-
glucuronosyltransferase activity.
|
Cross-references |
BRENDA | 2.4.1.226 |
EC2PDB | 2.4.1.226 |
ExplorEnz | 2.4.1.226 |
PRIAM enzyme-specific profiles | 2.4.1.226 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.226 |
IUBMB Enzyme Nomenclature | 2.4.1.226 |
IntEnz | 2.4.1.226 |
MEDLINE | Find literature relating to 2.4.1.226 |
MetaCyc | 2.4.1.226 |
Rhea expert-curated reactions | 2.4.1.226 |
UniProtKB/Swiss-Prot |
Q9P2E5, CHPF2_HUMAN | Q86X52, CHSS1_HUMAN | Q6ZQ11, CHSS1_MOUSE |
Q8IZ52, CHSS2_HUMAN | Q6IQX7, CHSS2_MOUSE | Q70JA7, CHSS3_HUMAN |
Q5DTK1, CHSS3_MOUSE | Q7Z1Z1, CHSSA_CAEEL | P45895, CHSSB_CAEEL |
Q8L0V4, CHS_ECOLX | Q9CMP0, CHS_PASMU | Q7BLV3, HAS_PASMD |
|
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