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PROSITE entry PS01070


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General information about the entry

Entry name [info] NUCLEASE_NON_SPEC
Accession [info] PS01070
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-JUL-1999 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00821
Associated ProRule [info] PRU10047

Name and characterization of the entry

Description [info] DNA/RNA non-specific endonucleases active site.
Pattern [info] 
D-R-G-H-[QLIM]-x(3)-[AG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 17 in 17 different sequences
Number of true positive hits 12 in 12 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 1
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 70.59 %
Recall (true positives / (true positives + false negatives)) 92.31 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 12 sequences 

NUC1_CUNEE  (P81203), NUC1_SYNRA  (P81204), NUC1_YEAST  (P08466), 

NUCA_NOSS1  (P38446), NUCA_SERMA  (P13717), NUCE_STRPN  (P0A3S3), 
NUCE_STRR6  (P0A3S4), NUCG_BOVIN  (P38447), NUCG_CAEEL  (Q95NM6), 
NUCG_HUMAN  (Q14249), NUCG_MOUSE  (O08600), PNU1_SCHPO  (Q10480)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

EXOG_HUMAN  (Q9Y2C4)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			5 sequences
			


			
FFSA_ASPFV  (A0A7L8UVC9), FHCA_METEA  (C5B137), MURD_PSEPF  (Q3K742), 

			
TGA6_ARATH  (Q39140), Y4XK_SINFN  (P55703)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			7 PDB
			


			1G8T; 1QAE; 1QL0; 1SMN; 3S5B; 4E3Y; 4QN0